Decker has been featured in pictorials in Teen Vogue, Cosmopolitan, FHM, and Glamour, and has modeled for The Gap, Intimissimi and Victoria's Secret. She has appeared in music videos for Jimmy Buffett and the band 3 Doors Down. She is also an avid Tar Heel basketball and Carolina Panthers fan. In 2005, within two months of moving to New York City, Decker auditioned for the Sports Illustrated Swimsuit Edition, in which she first appeared in 2006. She was again featured in the 2007 edition, and hosted the 2007 behind-the-scenes television special.
She returned for a third consecutive time in 2008. Decker was chosen cover girl for the 2010 edition, shot on location in the Maldives islands. In 2007, she had a recurring feature on the CNN/SI website called "She Says, Z Says," along with Paul Zimmerman, discussing NFL football games of the week. Decker appeared in the 2007 made-for-television Lipshitz Saves the World.She worked for a period in Australia. She joined the cast of Sports New York to discuss the 2010 NCAA basketball tournament.In 2008, Decker rang the New York Stock Exchange bell with other Sports Illustrated models.Decker is represented by Marilyn Agency.Decker made a guest appearance on NBC's Chuck, where she played a model applying to be a "Buy More Girl."
She made a guest appearance on USA Network's Royal Pains on July 30, 2009. Decker played swimsuit model Rachel, while Peter Jacobson played Alan, her nebbish husband.On February 8, 2010, David Letterman announced on Late Show with David Letterman that Decker had been chosen as the 2010 Sports Illustrated Swimsuit covermodel.Calling her selection "the news of a lifetime," Decker admitted that her mother cried when she heard her daughter would grace the cover. Decker served as a guest judge in the 5th cycle from Germany's Next Topmodel. She was reportedly considered for the lead female role in Transformers: Dark of the Moon.
Decker won Esquire magazine's 2010 "Sexiest Woman Alive" bracket challenge.MTV Networks' NextMovie.com named her one of the 'Breakout Stars to Watch for in 2011'.Brooklyn is the female lead, Sam, in the Battleship movie based on the game of the same nameBrooklyn is playing a female lead named Skyler who is the young wife of Dennis Quaid's character, Ramsey, who finds out she is pregnant with twins in, the upcoming What to Expect When You're Expecting movie based on the book of the same name.She was named one of the "100 Hottest Women of All-Time" by Men's Health.
She says, “I have a top-five list, and Gisele [Bundchen] is my number one. So she can do no wrong in my eyes. Everyone has a top-five list of thier biggest crushes, you know? Usually it’s guys on my list, but Gisele is just so perfect in every way.”
- Ranked #5 in the Top Sexiest Models list by models.com.
- Ranked #2 in the Maxim Hot 100 women list (2010).
- Voted #31 in the 2010 Ask Men list of "top 99 most desirable women." In 2011 she was voted #36.
- Named #36 Sexiest Woman by the Spanish version of DT magazine (2011).
- Voted #33 on Ask men's top 99 'most desirable' celebrity women of 2012.